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主页 --- News --- 3-Bromocinnamic acid in the application of treating chronic glomerulonephritis

3-Bromocinnamic acid in the application of treating chronic glomerulonephritis

Promulgator: :admin   Send date: :2011-11-28 09:46 Visitor: :

       Chronic glomerulonephritis is a clinical common disease, difficult diseases, persistent disease in patients with chronic glomerulonephritis, clinical remission can be, but it is difficult fully recovered, and finally the development of end-stage renal failure leading to death. Therefore, to identify the pathogenesis of chronic glomerulonephritis and find the best treatment options and effective drugs, the medical profession in recent decades has become a research hotspot.

More recently, researchers finally have a big breakthrough. scientists  found 3-bromocinnamicacid significantly inhibited the proliferation of rat mesangial cells by observing the abnormal proliferation of bromine acid-induced rat mesangial cells, Experimental conditions in the double staining, fluorescence microscopy can significantly distinguish between the role of bromine acid cells 24 hours after the early middle and late apoptotic cells and apoptotic cells.FCM (flow cytometry) Quantitative analysis showed that the number of mesangial cells 3-bromocinnamicand the acid concentration in a dose-dependent manner (P <0.05). Compared with control group, 1000,200 and 40μg/ml bromine acid groups between SOD and GSH-PX activity was significantly higher (P <0.05), while MDA content was significantly lower (P <0.05). SOD is short for superoxide dismutase, is an active substance derived from living organisms, can eliminate the organism in the metabolic process of harmful substances; GSH-PX is called glutathione peroxidase, can protect the cell membrane structure and function; MDA MDA is short, can increase cell membrane damage. In addition, Casepase activity detected 3-bromocinnamicacid can increase cell casepase-3 expression and a dose-dependent increase. That acid can induce between bromine mesangial cell apoptosis and inhibit their proliferation. The experts further study found that cinnamic acid and bromine between closely related to antioxidant effects. This antioxidant activity by decreasing the pathological state of over-expression of NF-KB , increased MMP-9 to repair the damage of kidney tissue.

There is no doubt, 3-bromocinnamicacid drugs to treat glomerulonephritis most effective ingredients, which will give patients with chronic glomerulonephritis tremendous vision.